Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride → 18-Benzoyloxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | 18-Hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-ene | HCID 72260127 | — |
| 생성물 | 18-Benzoyloxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene | HCID 72445374 | 48% |
반응 단계
Prepared by way of method I using 18-hydroxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo[14.3.0.04,6]-nonadec-7-ene (100 mg, 0.175 mmol) and benzoyl chloride (61 μL, 0.53 mmol). The final trituration (diethyl ether/hexane) and filtration gave 56 mg (48%) of 18-benzoyloxy-14-tert-butoxycarbonylamino-4-cyclopropylsulfonylaminocarbonyl-2,15-dioxo-3,16-diaza-12-oxatricyclo-[14.3.0.04,6]-nonadec-7-ene as a white powder: 99.0% pure (HPLC), MS m/z 673 (M−H)−, HRMS: calcd. 675.2700 and found 675.2709 (M+H)+, mp 135-137° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772183B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-57aae7c1698141a2984a84bc173924e1 |
| 출처 메모 | uspto-grants-2010_08 |