Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Acetyl-4-(2-hydroxyethyl)piperazine | HCID 4739629 | 65% |
반응 단계
A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772229B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-d4d753808d88424382dcf7134625b815 |
| 출처 메모 | uspto-grants-2010_08 |