1,1'-Carbonyldiimidazole → tert-Butyl 4-(1-(2,4-dimethoxybenzyl)-1,2-dihydro-2-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)piperidine-1-carboxylate

https://huagongshe.com/ko/reaction/501101

참여 물질

역할	이름	HCID	투입량
반응물	1,1'-Carbonyldiimidazole	HCID 68263	—
반응물	Tert-butyl 4-((2-(2,4-dimethoxybenzylamino)pyridin-3-yl)methylamino)piperidine-1-carboxylate	HCID 22293293	—
용매	Water	HCID 962	—
용매	Dimethylformamide	HCID 6228	—
생성물	tert-Butyl 4-(1-(2,4-dimethoxybenzyl)-1,2-dihydro-2-oxopyrido[2,3-d]pyrimidin-3(4H)-yl)piperidine-1-carboxylate	HCID 22293273	—

반응 조건

온도	150 °C

반응 단계

Carbonyldiimidazole (0.65 g, 4.0 mmol) was added to a solution of the material from Step C in dimethylformamide (20 mL) and the reaction was heated to 150° C. After 1 d, further carbonyldiimidazole (0.65 g, 4.0 mmol) was added and the reaction heated for an additional 3 h. The reaction was diluted with water and extracted with dichloromethane, and the organic phase dried over sodium sulfate. The crude product was purified by chromatography (silica gel, 20 to 80% ethyl acetate in methylene chloride gradient elution), which gave the title compound (0.35 g). MS 483.3 (M+1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07772224B2
출처 데이터셋	uspto-grants-2010_08
ORD ID	ord-7f382fb6fb0444f08832d00bb60a0a1d
출처 메모	uspto-grants-2010_08