Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(6-Nitroindolin-1-yl)ethanone → 1-Acetyl-6-aminoindoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(6-Nitroindolin-1-yl)ethanone | HCID 258566 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Acetyl-6-aminoindoline | HCID 258564 | 99% |
반응 단계
1-Acetyl-6-nitroindoline (3.8 g, 18.3 mmol) is suspended in EtOAc (200 mL). Pd/C (650 mg, 10%) is added, and the mixture is hydrogenated at 40-55 p.s.i. for 2 hours. The mixture is then filtered through celite. The filtrate is concentrated, and the residue is triturated with ether to yield 1-acetyl-6-aminoindoline (3.18 g, 99%) as an orange solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772271B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-3176c00d69924d3187679b4c09e95813 |
| 출처 메모 | uspto-grants-2010_08 |