Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbonochloridic acid, octyl ester → ethyl 3-[[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-3-ylamino]propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbonochloridic acid, octyl ester | HCID 81956 | — |
| 반응물 | 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride | HCID 18412473 | — |
| 용매 | Dichloromethane ethanol | HCID 21584144 | — |
| 생성물 | ethyl 3-[[1-methyl-2-[[4-(N-octoxycarbonylcarbamimidoyl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-3-ylamino]propanoate | HCID 140443503 | 35% |
반응 단계
Prepared analogously to Example 90 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(3-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and n-octyl chloroformate. Yield: 35% of theory, C36H45N7O5 (655.8); Rf value: 0.28 (silica gel; dichloromethane/ethanol=19:1); EKA mass spectrum: (M+H)+=656; (M+2H)++=328.7.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710055B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-889aebb0368e40aa9d1a5a9f0df5d1be |
| 출처 메모 | uspto-grants-2004_03 |