Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-[4-(Piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-chloro-N-phenylquinazolin-4-amine | HCID 317908 | — |
| 반응물 | 4-(Piperidin-1-yl)aniline | HCID 413501 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-[4-(Piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride | HCID 22639809 | — |
반응 단계
A mixture of 2-chloro-4-phenylamino-quinazoline (0.18 g) and N-(4-aminophenyl)-piperidine (0.164 g) is heated for 3 min to produce a melt which is dissolved in isopropanol (4 ml). 4 N HCl in dioxane (1 ml) is added. Recrystallization from ethanol and diethylether yields 2-[4-(piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride, Rf (A1) 0.64, FAB-MS: (M+H)+=396. m.p.: (decomposition).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713265B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-3d7a4c451e044c15b84fbe6eaeee2d6b |
| 출처 메모 | uspto-grants-2004_03 |