Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (2R)-2-(4-Chlorobenzenesulfonylamino)-4-methylpentanoic acid amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 4-Chlorobenzenesulfonyl chloride | HCID 7398 | — |
| 반응물 | (R)-2-Amino-4-methylpentanamide | HCID 7271815 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | (2R)-2-(4-Chlorobenzenesulfonylamino)-4-methylpentanoic acid amide | HCID 59001058 | — |
반응 단계
The above polymer-bound D-Leu-NH2 (20 g) was treated with CH2Cl2 (150 mL), pyridine (100 mL) and 4-chlorophenylsulfonyl chloride (20.0 g, 94.8 mmol). The mixture was shaken for 24 h, drained, washed with DMF (4×200 mL), CH2Cl2 (4×200 mL) and concentrated to give polymer-bound (R)-2-(4-chlorobenzenesulfonylamino)-4-methylpentanoic acid amide as a yellow resin (22 g). The completion of the reaction and the loading of the resin (0.57 mmol/g) were determined by the treatment of 50 mg of the resin with 10% (v/v) TFA/CH2Cl2 (2 mL) to give 8.7 mg of (R)-2-(4-chlorobenzenesulfonylamino)-4-methylpentanoic acid amide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07786122B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-466db7542208430f8cdf772885ad7a2d |
| 출처 메모 | uspto-grants-2010_08 |