Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(4-bromo-2-fluorophenyl)acetamide → N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(4-bromo-2-fluorophenyl)acetamide | HCID 67593 | — |
| 반응물 | (4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)boronic acid | HCID 10987806 | — |
| 생성물 | N-[4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-2-fluorophenyl]-acetamide | HCID 23509628 | — |
반응 단계
Prepared according to procedure B from 4′-bromo-2′-fluoroacetanilide and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. Off white solid, mp 245-247° C. 1H-NMR (DMSO-d6) δ 10.3 (s, 1H), 9.79 (s, 1H), 7.95 (t, 1H, J=8.4 Hz), 7.56-7.63 (m, 3H), 7.47 (dd, 1H, J=1.64, 8.47 Hz), 6.95(d, 1H, J=8.9 Hz), 2.1 (s, 3H), 1.67 (s, 6H); MS+APCI [M+H]+m/z 329. Anal. Calc. For C18H17N2 FO3; C, 65.85; H, 5.22; N, 8.53. Found: C, 65.46; H, 5.24; N, 8.12.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713478B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-d24c2822817d4911bca185e9654cd3a6 |
| 출처 메모 | uspto-grants-2004_03 |