참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-Methylmethanesulfonamide | HCID 97632 | — |
| 반응물 | Ethyl 6-bromo-1-benzothiophene-2-carboxylate | HCID 13567982 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | N-((6-bromobenzo[b]thiophen-3-yl)methyl)-N-methylmethanesulfonamide | HCID 67066523 | — |
반응 단계
A mixture of the product from Example 76, Part D (0.100 g, 0.382 mmol), N-methylmethanesulfonamide (45.9 mg, 0.421 mmol) and potassium carbonate (0.127 g, 0.918 mmol) in N,N-dimethylacetamide (5 mL). The mixture was stirred at 80° C. for 11 h, cooled to room temperature and partitioned between diethylether and water (3×), dried over mgSO4, filtered and concentrated in vacuo to give the title compound as a colorless waxy solid (0.128 g, quant.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09095590B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_08 |
|---|
| ORD ID | ord-ee456261a9e04869a9d86a93c1de3dcd |
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| 출처 메모 | uspto-grants-2015_08 |
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