Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Phenethylisoselenocyanate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Triphosgene | HCID 94429 | — |
| 반응물 | Formamide, N-(2-phenylethyl)- | HCID 140995 | — |
| 반응물 | Selenium | HCID 6326970 | — |
| 반응물 | Benzyl Isoselenocyanate | HCID 12506035 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Phenethylisoselenocyanate | HCID 25060470 | 95% |
반응 단계
(AS3.091) A mixture of phenylethylformamide (g, 1.5 mmol), triethylamine (6.4 mmol), 4 Å molecular sieves (g), triphosgene (0.8 mmol), and selenium powder (3.0 mmol) in CH2Cl2 was refluxed and worked up as mentioned for 2a. The crude residue thus obtained was purified by silica gel column chromatography (EtOAc/hexanes 2:98) to give 0.96 g (95%) of 2b as an oil. 1H NMR (CDCl3) δ 3.03 (t, 2H, J=6.9 Hz), 3.81 (t, 2H, J=6.9 Hz) 7.20-7.38 (m, 5H); HRMS (EI) calcd for C9H9NSe, 210.9895. found, 210.9892.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09096505B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-45b41c2d14c144e5bf8cbaf74e340921 |
| 출처 메모 | uspto-grants-2015_08 |