Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl chloroformate → Benzyl 4-benzoylpiperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Benzoylpiperidine hydrochloride | HCID 2724437 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Benzyl 4-benzoylpiperidine-1-carboxylate | HCID 57779495 | — |
반응 단계
To a stirring suspension of phenyl(piperidin-4-yl)methanone hydrochloride 86 (1.97 g, 8.73 mmol) and potassium carbonate (3.62 g, 26.2 mmol) in THF (40 mL) at 0° C. was added benzyl chloroformate (1.433 mL, 10.04 mmol) and the reaction mixture was allowed to slowly warm to room temperature and stirred for 2 h. The mixture was diluted with ethyl acetate, washed with brine, water, dried over Na2SO4, filtered and concentrated to afford compound 87 quantitative yield. LRMS (ESI): (calc) 323.39 (found) 324.31 (MH)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09096565B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-b2d89e74c61944c2a87bd85c7ce2a969 |
| 출처 메모 | uspto-grants-2015_08 |