Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Methylsulfonyl)ethanamine → Lapatinib
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Methylsulfonyl)ethanamine | HCID 4340561 | — |
| 반응물 | (5-(4-(4-((3-Fluorobenzyl)oxy)-3-chloroanilino)-6-quinazolinyl)-2-furancarboxaldehyde | HCID 11181296 | — |
| 생성물 | Lapatinib | HCID 208908 | — |
반응 단계
Prepared according to Procedure D from 5-(4-{3-chloro-4-(3-fluorobenzyloxy)-anilino}-6-quinazolinyl)-furan-2-carbaldehyde (0.6 equiv) and 2-methanesulphonyl-ethylamine (1 equiv). 1H NMR 400 MHz (DMSO-d6) 9.60 (bs, 1H); 9.32 (bs, 1H); 8.82 (bs, 1H); 8.34 (d, 1H); 8.0 (s, 1H); 7.88 (d, 1H); 7.74 (d, 1H); 7.45 (m, 1H); 7.34-7.23 (m, 4H); 7.17 (m, 1H); 6.83 (d, 1H); 5.27 (s, 2H); 4.42 (s, 2H); 3.59 (m, 2H); 3.40 (m, 2H, obscured by waterpeak); 3.12 (s, 3H); MS m/z 581 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713485B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-ba7c9aa36a4542e9891af4ebd28194f0 |
| 출처 메모 | uspto-grants-2004_03 |