Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Fluoride → 5-Bromo-2-(trifluoromethyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 반응물 | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| 반응물 | 5-Bromo-2-iodopyrimidine | HCID 7006651 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Bromo-2-(trifluoromethyl)pyrimidine | HCID 33697963 | 16.7% |
반응 단계
A mixture of 5-bromo-2-iodo-pyrimidine (30 g, 0.11 mol), TMSCF3 (30 g, 0.21 mol), KF (9.2 g, 0.16 mol) and CuI (30 g, 0.16 mol) in DMF (300 mL) was stirred at room temperature overnight. The reaction mixture was quenched by NH3.H2O (600 mL) and extracted with EtOAc (500 mL×3). The organic layer was washed with brine, dried over Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel (Petroleum ether) to give 5-bromo-2-trifluoromethyl-pyrimidine (4 g, yield: 16.7%). 1H NMR (CDCl3 400 Hz): δ8.90 (s, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102591B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-a5e49ed79b414c7f9c2e3af28f397992 |
| 출처 메모 | uspto-grants-2015_08 |