Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(2,3-Dimethoxybenzoyl)pyridine → (2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(2,3-Dimethoxybenzoyl)pyridine | HCID 428549 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (2,3-Dimethoxyphenyl)(piperidin-4-yl)methanol | HCID 10890362 | 92.5% |
반응 단계
A solution of 4-(2,3-dimethoxybenzoyl)pyridine (12) (2.10 g, 8.6 mmol) in MeOH (10 mL) is treated with 5% Rh/alumina (0.72 g). The mixture is hydrogenated in a Parr shaker at 55 psig for 22 hours. After filtration through Celite7 filter aid, the filtrate is concentrated at reduced pressure to give the title compound (11) as a solid (2.0 g, 92% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06713627B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-7e3f5ba32de04fa7ba8b4f049ccb6fe2 |
| 출처 메모 | uspto-grants-2004_03 |