Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethanolamine → (E)-N-methacryloylbut-2-enamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethanolamine | HCID 7618 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Piperlongumine | HCID 637858 | — |
| 반응물 | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (E)-N-methacryloylbut-2-enamide | HCID 72205393 | 47% |
반응 단계
Experimental Procedure: Triphenylphosphine (79.0 mg, 0.30 mmol) and DIAD (61.0 mg, 0.30 mmol) were dissolved to a 1:1 mixture of THF and toluene (2 mL); then mono-demethylated piperlongumine (46.0 mg, 0.15 mmol) was added. After 10 min, triethanolamine (6.80 mg, 0.05 mmol) was added to the mixture. The reaction was stirred at room temperature for 3 h. At the end, the solvent was evaporated under vacuum. The crude product was purified by preparative TLC(CH2Cl2/MeOH=9/1) to afford the desired product in 47% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09108923B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-b05da1356f044b44bb3def8560039b9a |
| 출처 메모 | uspto-grants-2015_08 |