참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Methyl 6-(hydroxymethyl)picolinate | HCID 11513809 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 6-(chloromethyl)pyridine-2-carboxylate | HCID 53404482 | 101.4% |
반응 단계
SOCl2 (57 g, 0.48 mol) was added to a solution of methyl 6-(hydroxymethyl)picolinate 66 (40.0 g, 0.239 mol) (Chem. Eur. J. 2006, 12, 6393-6402) in dichloromethane (500 mL) at room temperature. The mixture was stirred at 40° C. for 1 h and sat. aq K2CO3 was added to adjust the pH to 9. The mixture was extracted with CH2Cl2 and the combined organics were washed with brine, dried (Na2SO4), and concentrated in vacuo to give 67 (45 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09326986B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_05 |
|---|
| ORD ID | ord-3040965c9beb4b7faa1e882259a44048 |
|---|
| 출처 메모 | uspto-grants-2016_05 |
|---|
