Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitrobenzenesulfonyl chloride → 4-Bromo-1-[(4-nitrophenyl)sulfonyl]-1H-indole-6-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitrobenzenesulfonyl chloride | HCID 7404 | — |
| 반응물 | 2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amine | HCID 3513851 | — |
| 반응물 | 4-bromo-1H-indole-6-carbonitrile | HCID 24728883 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Bromo-1-[(4-nitrophenyl)sulfonyl]-1H-indole-6-carbonitrile | HCID 66692272 | — |
반응 단계
4-Bromo-1H-indole-6-carbonitrile (207 mg), PS-BEMP (900 mg) and 4-nitrobenzenesulfonyl chloride (380 mg) were weighed to a round bottom flask, then N,N-Dimethylformamide (4 ml) was added and the reaction was stirred at RT. The reaction was filtered and washed with DMF. The DMF was evaporated and the residue was dissolved in DCM:methanol and passed through a 5 g SAX cartridge (preconditioned with methanol) washing with DCM:methanol. The residue was evaporated to afford the title compound, 360 mg as a pale orange solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09326987B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-b012c838402e4d64b66e3aab0f2606b9 |
| 출처 메모 | uspto-grants-2016_05 |