참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Chloro-2-methylbenzoxazole | HCID 29510 | — |
| 반응물 | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | HCID 11269872 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 생성물 | Benzoxazole | HCID 9228 | — |
반응 단계
To form 5-vinyl-2-methylbenzoxazole (4aa), the general procedure was followed using 5-chloro-2-methylbenzoxazole (3d) (167 mg, 1.01 mmol), vinyl MIDA boronate (2g) (218 mg, 1.19 mmol), SPhos (42 mg, 0.10 mmol) and Pd(OAc)2 (11 mg, 0.050 mmol). The reaction time and temperature were modified so that the reaction mixture was heated to 100° C. for 2 h. Benzoxazole 4aa was isolated as a pale golden liquid (152 mg, 96%). TLC (hexanes:EtOAc 3:1) Rf=0.46, visualized by UV (254 nm).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09328102B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_05 |
|---|
| ORD ID | ord-da86b1c1e8ba49c596ea65369b3e6128 |
|---|
| 출처 메모 | uspto-grants-2016_05 |
|---|
