Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 52242생성일: 2026년 10월 24일
3-Chloro-p-toluonitrile → 3-(2-chloro-6-fluorophenyl)-5-(3-chloro-4-methylphenyl) 1-methyl-1H-1,2,4-triazole
https://huagongshe.com/ko/reaction/52242
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Chloro-p-toluonitrile | HCID 88894 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | N-methyl-N-(p-toluenesulfonyl)-2-chloro-6-fluorobenzohydrazonoyl chloride | HCID 54347086 | — |
| 용매 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 생성물 | 3-(2-chloro-6-fluorophenyl)-5-(3-chloro-4-methylphenyl) 1-methyl-1H-1,2,4-triazole | HCID 21463647 | 55.1% |
반응 단계
A mixture of N-methyl-N-(p-toluenesulfonyl)-2-chloro-6-fluorobenzohydrazonoyl chloride (7.50 g), 3-chloro-4-methylbenzonitrile (3.33 g), anhydrous aluminum chloride (3.00 g) and o-dichlorobenzene (20 ml) is stirred at an oil bath temperature of 140° C. for 1 hour. After cooling, it is washed with saline. Then, it is dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The concentrate is purified by silica gel column chromatography using mixed solvent of hexane-ethyl acetate as eluent to give 3.70 g of desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05616594 |
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| 출처 데이터셋 | uspto-grants-1997_04 |
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| ORD ID | ord-d09da8cf964749938e77b8540c98d8c7 |
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| 출처 메모 | uspto-grants-1997_04 |
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