Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → HCID 70495691, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Methyl p-coumarate | HCID 92203 | — |
| 반응물 | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| 반응물 | Bromopropanol | HCID 12887879 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 70495691 | HCID 70495691 | — |
반응 단계
To a solution 5 g (28.1 mmol) of 4-Hydroxycinnamic acid methyl ester, 4.9 g (35.1 mmol) of 4 bromopropanol, 9.2 g (35.1 mmol) of triphenylphosphine in 100 mL of THF are added 7.1 g (35.1 mmol) of diisopropylazodicarboxylate under inert atmosphere. The solution is heated up to reflux and allowed to stir overnight. After 20 hours, the reaction mixture is partitioned between EtOAc and water. The organic phase is washed repeatedly with water, dried over sodium sulphate, filtered and concentrated by rotary evaporation to give 7.5 g of (methyl (2E)-3-[4-(3-bromopropoxy)phenyl]prop-2-enoate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09334366B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-db9adabeb650425a934951281dbbebef |
| 출처 메모 | uspto-grants-2016_05 |