Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Difluoromethyl-phenylboronic acid → (R)-5-(3-Difluoromethyl-phenyl)-1-(2-methoxy-1-methyl-ethyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Difluoromethyl-phenylboronic acid | HCID 44717244 | — |
| 반응물 | (R)-5-Bromo-1-(2-methoxy-1-methyl-ethyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide | HCID 89978794 | — |
| 생성물 | (R)-5-(3-Difluoromethyl-phenyl)-1-(2-methoxy-1-methyl-ethyl)-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid 4-methanesulfonyl-benzylamide | HCID 89978697 | — |
반응 단계
Example 44 is prepared following the procedure for Example 24.1, substituting preparation 24 with preparation 43c and replacing 3-(trifluoromethyl)phenylboronic acid with 3-(difluoromethyl)phenylboronic acid. ESI mass spectrum: [M+H]+=519; Retention time HPLC: 0.97 min (Z018_S04).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09340507B2 |
| 출처 데이터셋 | uspto-grants-2016_05 |
| ORD ID | ord-fca7e6965e9f4e1ba99e5104a0a37065 |
| 출처 메모 | uspto-grants-2016_05 |