Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 527481생성일: 2026년 10월 24일
Diisopropylethylamine → {(3R,4S)-4-(4-Chloro-phenyl)-1-[1-(5-cyano-pyrimidin-2-yl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-ethyl-carbamic acid 4-fluoro-phenyl ester
https://huagongshe.com/ko/reaction/527481
참여 물질
| 역할 | 이름 | HCID | 투입량 |
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| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Chloro-5-pyrimidinecarbonitrile | HCID 21473592 | — |
| 반응물 | [(3R,4S)-4-(4-Chloro-phenyl)-1-(piperidine-4-carbonyl)-pyrrolidin-3-yl]-ethyl-carbamic acid 4-fluoro-phenyl ester | HCID 58312678 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | {(3R,4S)-4-(4-Chloro-phenyl)-1-[1-(5-cyano-pyrimidin-2-yl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-ethyl-carbamic acid 4-fluoro-phenyl ester | HCID 53247358 | — |
반응 단계
A mixture of 94.7 mg (0.2 mmol)[(3R,4S)-4-(4-Chloro-phenyl)-1-(piperidine-4-carbonyl)-pyrrolidin-3-yl]-ethyl-carbamic acid 4-fluoro-phenyl ester, 83.7 mg (0.3 mmol) 2-chloropyrimidine-5-carbonitrile and 129 mg (1 mmol) DIPEA in 2.5 mL DMF was shaken a for 22 h at 65° C. The mixture was subjected to preparative HPLC purification on reversed phase eluting with a gradient formed from acetonitrile, water and NEt3. The product containing fraction were evaporated to access 58 mg (51%) of the title compound as off-white solid. MS m/e: 577.3 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09346786B2 |
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| 출처 데이터셋 | uspto-grants-2016_05 |
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| ORD ID | ord-7d1abb71843748acb87097cbf899d5a9 |
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| 출처 메모 | uspto-grants-2016_05 |
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