Cesium carbonate → N-(2-(6-amino-8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)-purin-9-yl)-ethyl)-methanesulfonamide

https://huagongshe.com/ko/reaction/527849

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	N-(2-bromoethyl)methanesulfonamide	HCID 285330	—
반응물	HCID 178508697	HCID 178508697	—
용매	Dimethylformamide	HCID 6228	—
생성물	N-(2-(6-amino-8-(6-iodo-benzo[1,3]dioxol-5-ylsulfanyl)-purin-9-yl)-ethyl)-methanesulfonamide	HCID 66554616	27.3%

반응 조건

온도	25 °C

반응 단계

To a solution of 8-((6-iodobenzo[d][1,3]dioxol-5-yl)thio)-9H-purin-6-amine (100 mg, 0.24 mmol) in 5 mL of dry DMF was added N-(2-bromoethyl)methanesulfonamide (150 mg, 0.7 mmol) and Cs2CO3 (150 mg, 0.46 mmol). The resulting mixture was stirred at a temperature of about 25° C. for 3 hrs, condensed under reduced pressure and purified by flash chromatography to provide compound WS35 as white solid (35 mg, 27% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09346808B2
출처 데이터셋	uspto-grants-2016_05
ORD ID	ord-180331ac5a5642bd9d365c396ac11e9e
출처 메모	uspto-grants-2016_05