참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 3-Chloropyridine-2-carboxylic acid | HCID 824632 | — |
| 반응물 | 4-Iodo-N1-methylbenzene-1,2-diamine | HCID 66064280 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | HCID 71247910 | HCID 71247910 | 73.4% |
반응 단계
A mixture of 4-iodo-N1-methyl-benzene-1,2-diamine (850 mg), 3-chloro-pyridin-2-carboxylic acid (590 mg), WSC (790 mg), HOBt (46 mg), and pyridine (10 ml) was stirred at 100° C. for 12 hours. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 2-(3-chloro-pyridin-2-yl)-5-iodo-1-methyl-1H-benzimidazole (930 mg), which is hereinafter referred to as “intermediate compound (M6-21)”.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09353110B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_05 |
|---|
| ORD ID | ord-c8ba6e03cd7f44a28e1ac82f19806503 |
|---|
| 출처 메모 | uspto-grants-2016_05 |
|---|
