Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Cbz-aminoglutarimide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-Amino-2,6-piperidinedione | HCID 134508 | — |
| 반응물 | 1H,3H-furo(3,4-c)pyridine-1,3-dione | HCID 278398 | — |
| 생성물 | Cbz-aminoglutarimide | HCID 67017964 | 17% |
반응 단계
With reference to Scheme 4 below, azathalidomide was prepared from aminoglutarimide and commercial pyridine-3,4-dicarboxylic anhydride. Cbz-aminoglutarimide was deprotected by hydrogenolysis with catalyst palladium hydroxide on carbon (10%) to form aminoglutarimide. Pyridine-3,4-dicarboxyic anhydride was refluxed with aminoglutarimide in the presence of triethylamine to yield azathalidomide 11 in the total yield of 17% from Cbz-aminoglutarimide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08853253B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-ce699545f7fa4c82baa51d40f8c107be |
| 출처 메모 | uspto-grants-2014_10 |