Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → ethyl 2-chloro-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Ethyl 2,4-dichloropyrimidine-5-carboxylate | HCID 104020 | — |
| 반응물 | 1-methyl-1H-indol-4-amine | HCID 22170307 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | ethyl 2-chloro-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxylate | HCID 58014943 | — |
반응 단계
To a solution of ethyl 2,4-dichloropyrimidine-5-carboxylate (328 mg, 1.48 mmol) and 1-methyl-1H-indol-4-amine (260 mg, 1.78 mmol) in CH3CN (6 mL) at room temperature, DIEA (0.4 mL, 2.22 mmol) was added. The mixture was stirred at room temperature for 24 h. Water (15 mL) was added to induce precipitation. The precipitate was collected, dried on vacuum to give ethyl 2-chloro-4-(1-methyl-1H-indol-4-ylamino)pyrimidine-5-carboxylate as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08853230B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-ef6c05deb3414e30b3b638c5d5d80c87 |
| 출처 메모 | uspto-grants-2014_10 |