Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4,4-Dimethyl-2-(4'-methanesulfonyloxymethylbipbenyl-2-yl)oxazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | 4,4-Dimethyl-2-(4'hydroxymethylbiphenyl-2-yl)oxazoline | HCID 11065876 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4,4-Dimethyl-2-(4'-methanesulfonyloxymethylbipbenyl-2-yl)oxazoline | HCID 15380878 | 99.1% |
반응 단계
2.0 g (7.1 mmol) of 4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline and 1.43 g (14.1 mmol) of triethylamine were dissolved in methylene chloride (20 ml). A solution of 0.98 g (8.6 mmol) of methanesulfonyl chloride in methylene chloride (10 ml) was dropwise added thereto under cooling with salt-ice. After stirring for 8 hours as such, the reaction liquid was poured into water, followed by the extraction with methylene chloride. After washing with water and drying, vacuum concentration was conducted. 2.53 g of the title compound was obtained as an oil (yield 99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05618969 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-7c9204b934f345e6aa8ab56122a191e0 |
| 출처 메모 | uspto-grants-1997_04 |