Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 534700생성일: 2026년 10월 24일
Sulfuric Acid → (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl-pentan-3-yl 4-methylbenzenesulfonate
https://huagongshe.com/ko/reaction/534700
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | (alphaR)-alpha-[(1S)-2-(Dimethylamino)-1-methylethyl]-alpha-ethyl-3-methoxybenzenemethanol | HCID 9942979 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Cyclohexane | HCID 8078 | — |
| 생성물 | (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl-pentan-3-yl 4-methylbenzenesulfonate | HCID 56832993 | — |
반응 단계
Accordingly the compound (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol of Formula-V was charged in the solvent tetrahydrofuran and under stirring charged concentrated sulfuric acid at temperature of 20-30° C. The reaction mixture is stirred and charged methanesulfonic acid or para toluenesulfonic acid and solvent cyclohexane. Stirred and raised the temperature to reflux. Maintained the reaction mass at reflux temperature for 3-5 hours with simultaneous removal of water. Cooled the reaction mass to 20° C. and quenched with water. The pH of the quenched reaction solution was adjusted to 8-9 using dilute sodium hydroxide solution. The reaction solution was extracted with cyclohexane. Separated the organic layer and concentrated under reduced pressure to get the compound (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-yl methane sulfonate of Formula IXA or (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl-pentan-3-yl 4-methylbenzenesulfonate of Formula IXB.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08853456B2 |
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| 출처 데이터셋 | uspto-grants-2014_10 |
|---|
| ORD ID | ord-ea248a4580344c1b8f17e9ed117ceaeb |
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| 출처 메모 | uspto-grants-2014_10 |
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