Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → Tert-butyl {4-[4-(4-methoxybenzylamino)-3-(3-methoxyphenyl)pyrrolo[3,2-c]pyridin-1-yl]butyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | tert-butyl N-(4-bromobutyl)carbamate | HCID 10868765 | — |
| 반응물 | (4-methoxybenzyl)-(3-(3-methoxyphenyl)-1H-pyrrolo-[3,2-c]pyridin-4-yl]amine | HCID 59765091 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Tert-butyl {4-[4-(4-methoxybenzylamino)-3-(3-methoxyphenyl)pyrrolo[3,2-c]pyridin-1-yl]butyl)carbamate | HCID 59765096 | 102.8% |
반응 단계
450 mg (1.1 mmol) of (4-methoxybenzyl)-[3-(3-methoxyphenyl)-1H-pyrrolo-[3,2-c]pyridin-4-yl]amine from Example B3, 428 mg (1.7 mmol) of 4-(BOC-amino)butyl bromide and 0.9 g (2.8 mmol) of caesium carbonate in 60 ml of DMF are warmed to 60° C. over the course of 12 h. Aqueous work-up at RT and chromatographic purification gives 600 mg (82%) of a colourless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08859581B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-56aef82dd0ec4eaf9807051269131f47 |
| 출처 메모 | uspto-grants-2014_10 |