Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 4-Fluoro-2-(trifluoromethyl)aniline | HCID 67853 | — |
| 생성물 | N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamide | HCID 10560920 | 98% |
반응 단계
A solution of 2-amino-5-fluorobenzotrifluoride (2.025 g, 11.31 mmol, Aldrich) in acetic anhydride (10 mL) was stirred at room temperature for 12 h, and then most of the acetic anhydride was removed. The white needle crystals were collected by filtration, affording 2.445 g (98%) of 2-acetamido-5-fluorobenzotrifluoride. 1H NMR (CDCl3): δ 2.205 (S, 3H); 7.229-7.335 (m, 3H); 8.055 (dd, 1H, J1 =4.8 Hz, J2 =8.4 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05620979 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-a4fc415634834fa4b50ffb1937ce7782 |
| 출처 메모 | uspto-grants-1997_04 |