Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → Trifluoromethoxy phenyl-N-hydroxy-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 4-(Trifluoromethoxy)benzonitrile | HCID 67621 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 생성물 | Trifluoromethoxy phenyl-N-hydroxy-benzamide | HCID 86643274 | — |
반응 단계
To a solution of 4-Trifluoromethoxybenzonitrile (1.0 g, 5.0 mmol) in EtOH (20 mL) was added hydroxylamine hydrochloride (0.365 g, 5.0 mmol) and NaOH (0.212 g, 5.0 mmol). The resulting reaction mixture was refluxed for 15 h. After the completion of the reaction (TLC monitoring), the mixture was concentrated, added EtOH and filtered. The filtrate was evaporated in vacuo and used as such for the next step (crude yield 12.0 g, 66%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08865736B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-07e7c7730ae3400bb48e061324818fb3 |
| 출처 메모 | uspto-grants-2014_10 |