Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Methyl 5-methyl-2-(pyridin-4-yl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| 반응물 | Methyl 2-bromo-5-methylbenzoate | HCID 15110996 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl 5-methyl-2-(pyridin-4-yl)benzoate | HCID 86680841 | 48.5% |
반응 단계
A mixture of methyl 2-bromo-5-methylbenzoate (5.2 g), pyridine-4-boronic acid (4.2 g), sodium carbonate (4.8 g), tetrakis(triphenylphosphine)palladium(0) (1.3 g), water (10 mL) and DME (50 mL) was heated under reflux overnight under a nitrogen atmosphere. The reaction mixture was diluted with ethyl acetate, and filtered through silica gel. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (2.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08871766B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-70d53f886ec9452084e592c74feaa7d6 |
| 출처 메모 | uspto-grants-2014_10 |