Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane → 1-[3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N-tert.butyl-octahydro-cyclopenta[b]pyrrole-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2S,3S)-1,2-Epoxy-3-(Cbz-amino)-4-phenylbutane | HCID 9861019 | — |
| 반응물 | N-tert.butyl-octahydro-cyclopenta[b]pyrrole-2-carboxamide | HCID 19031947 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-[3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N-tert.butyl-octahydro-cyclopenta[b]pyrrole-2-carboxamide | HCID 57286140 | 92.7% |
반응 단계
A solution of 2.98 g of 3(S)-(benzyloxyformamido)-1,2(S)-epoxy-4-phenylbutane and 2.1 g of N-tert.butyl-octahydro-cyclopenta[b]pyrrole-2-carboxamide in 50 ml of ethanol was heated at reflux for 10 hours and the solvent was then removed by evaporation. Chromatography on silica gel using System H for the elution then gave 4.7 g of 1-[3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N-tert.butyl-octahydro-cyclopenta[b]pyrrole-2-carboxamide as a mixture of four diastereomers: MS: m/e 508 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05620987 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-7ff4e79b9bb74f40af70585bb8a7bf69 |
| 출처 메모 | uspto-grants-1997_04 |