Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Dimethylisoxazole-4-carbonyl Chloride → N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(3,5-dimethylisoxazol-4-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Dimethylisoxazole-4-carbonyl Chloride | HCID 2736265 | — |
| 반응물 | N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) | HCID 86636131 | — |
| 생성물 | N-[6-Chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-{1-[(3,5-dimethylisoxazol-4-yl)carbonyl]piperidin-4-yl}acetamide bis(trifluoroacetate) | HCID 86636204 | — |
반응 단계
The desired compound was prepared according to the procedure of Example A20, using N-[6-chloro-2,4,8,18,22-pentaazatetracyclo[14.3.1.1(3,7).1(9,13)]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaen-12-yl]-2-piperidin-4-ylacetamide tris(trifluoroacetate) and 3,5-dimethylisoxazole-4-carbonyl chloride as starting materials (43% yield). LCMS for C30H32ClN8O3 (M+H)+: m/z=587.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08871753B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-1acf629903d6419fbd25dac8d2a160f2 |
| 출처 메모 | uspto-grants-2014_10 |