Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → ethyl (Z)-3-methyl-4-[4-(1-methylpropoxy)phenoxyl]-2-butenoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-(1-Methyl-1-propyloxy)-phenol | HCID 13882004 | — |
| 반응물 | Ethyl-4-bromo-3-methyl-but-2-enoate (E/Z; 55/45) | HCID 53411540 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | ethyl (Z)-3-methyl-4-[4-(1-methylpropoxy)phenoxyl]-2-butenoate | HCID 13882007 | — |
반응 단계
To 4-(1-methylpropoxy)phenol (0.84 g, 5.06 mmol) and potassium carbonate (0.66 g, 0.48 mmol) in 10 ml of dimethylformamide (DMF) at 5° is added ethyl 4-bromo-3-methyl-2-butenoate (1.0 g, 0.48 mmol). The mixture is allowed to warm to RT and is stirred at RT for 20 hours. The reaction mixture is poured into water and extracted with ether. The organic layer is washed with 10% sodium hydroxide to remove any starting phenol, dried and the solvent removed. The product is purified by preparative thin layer chromatography (prep. TLC). The second main band is collected to give ethyl (Z)-3-methyl-4-[4-(1-methylpropoxy)phenoxyl]-2-butenoate, MS m/e 292 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04661617 |
| 출처 데이터셋 | uspto-grants-1987_04 |
| ORD ID | ord-d9b61874131343f995d550eec3fd420a |
| 출처 메모 | uspto-grants-1987_04 |