참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | 4-Nitro-1,2-bis(trifluoromethyl)benzene | HCID 2736166 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3,4-Bis(trifluoromethyl)aniline | HCID 1548579 | 99.5% |
반응 단계
A mixture of 261 mg (1.00 mmol) of 3,4-bis(trifluoromethyl)nitrobenzene and 989 mg (5.23 mmol) of SnCl2 in 6 mL of ethanol was heated at 70° C. for 2 h. It was evaporated to dryness and the residue was treated with 1N NaOH to pH=13. White precipitate was observed. The mixture was extracted by CHCl3 (4×8 mL). The extract was dried (MgSO4) and evaporated to leave 228 mg (99%) of oil. 1H NMR (CDCl3), 4.167 (sb, 2), 6.803 (d, 1, J=7.41), 7.026 (s, 1), 7.579 (d, 1, J=8.58). 19F NMR (CDCl3), 55.014 (q, 3), 56.919 (q, 3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05622952 |
|---|
| 출처 데이터셋 | uspto-grants-1997_04 |
|---|
| ORD ID | ord-3713417fb74441f18251fa41192506d9 |
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| 출처 메모 | uspto-grants-1997_04 |
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