Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → (E)-3-(1H-Indol-7-yl)acrylonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Diethyl (cyanomethyl)phosphonate | HCID 75676 | — |
| 반응물 | Indole-7-carboxaldehyde | HCID 2734629 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (E)-3-(1H-Indol-7-yl)acrylonitrile | HCID 19959103 | — |
반응 단계
Sodium hydride, 60% dispersion in mineral oil (0.10 g, 2.5 mmol) is added in portions over 10 minutes to a stirred solution of diethyl cyanomethylphosphonate (0.44 g, 2.5 mmol) in tetrahydrofuran (10 ml) cooled in ice. The mixture is stirred for 15 minutes then a solution of 7-indole carboxaldehyde (0.30 g, 2.1 mmol) in tetrahydrofuran (2 ml) is added dropwise. The mixture is stirred for 30 minutes, diluted with ethyl acetate, washed with water, dried and evaporated. The residue is chromatographed on silica in ethyl acetate-hexane (1:3) to give the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05622969 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-28339c89712f412387a749f34ff15d9b |
| 출처 메모 | uspto-grants-1997_04 |