Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole → 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole | HCID 568011 | — |
| 반응물 | 2-Bromo-1-(5-bromothiophen-2-yl)ethan-1-one | HCID 1988398 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2-Amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide | HCID 19040880 | 88% |
반응 단계
Dissolve 2.46 g (10 mmol) of 2-amino-1-(2-morpholinoethyl)benzimidazole in 120 ml of acetone with heating. Subsequently, add 5-bromo-2-bromoacetylthiophene. After stirring, leave at room temperature for 3 to 4 hours. The 2-amino-3-(5-bromo-2-thenoylmethyl)-1-(2-morpholinoethyl)benzimidazole hydrobromide precipitate is filtered, washed twice with 20 ml of acetone each time and with ether (20 ml) to obtain 4.7 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05623073 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-983dc768e9024bf4b4b1a009d593d4a6 |
| 출처 메모 | uspto-grants-1997_04 |