Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Methyl-9-(2-piperidinoehtyl)-3-(2-thenoyl)imidazo[1,2-a]benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 2-(2-imino-3-(2-(piperidin-1-yl)ethyl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-1-(thiophen-2-yl)ethanone hydrobromide | HCID 178508529 | — |
| 생성물 | 2-Methyl-9-(2-piperidinoehtyl)-3-(2-thenoyl)imidazo[1,2-a]benzimidazole | HCID 1049890 | — |
반응 단계
The bromide obtained in Step A is heated at reflux in 15 ml of acetic anhydride until completely dissolved. Cool and pour into 50 ml of cold water. Neutralise with a solution of sodium carbonate and extract twice with 10 ml of chloroform each time. Combine the organic phases, pass over a column of alumina and evaporate. Recrystallise the residue from ethyl acetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05623073 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-2e6e298763f54385911e75ee60b5a7f6 |
| 출처 메모 | uspto-grants-1997_04 |