Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluorobenzyl bromide → 4-((N-(4-fluorobenzyl)-1-phenylmethylsulfonamido)methyl)-cyclohexanecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluorobenzyl bromide | HCID 68021 | — |
| 반응물 | Phenylmethanesulfonyl chloride | HCID 74740 | — |
| 반응물 | (1R,4R)-Methyl 4-(aminomethyl)cyclohexanecarboxylate | HCID 12721444 | — |
| 생성물 | 4-((N-(4-fluorobenzyl)-1-phenylmethylsulfonamido)methyl)-cyclohexanecarboxylic acid | HCID 57450324 | — |
반응 단계
Prepared as in example 5-10 from phenylmethanesulfonyl chloride and methyl 4-(aminomethyl)cyclohexanecarboxylate and 1-(bromomethyl)-4-fluorobenzene. MS (M−H, 418), 1H NMR (400 MHz, DMSO-d6): δ, ppm: 0.639 (m, 2H), 0.897 (m, 2H), 1.034 (m, 1H), 1.467 d, broad, 2H, J=11.2 Hz), 1.709 (d, broad, 2H, J=11.2 Hz), 1.961 (m, 1H), 2.828 (d, 2H, J=7.6 Hz), 4.207 (s, 2H), 4.449 (s, 2H), 7.155 (t, 2H, J=9.2 Hz), 7.377 (m, 7H), 12 (s, broad, 1H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07939671B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-f8b4fcdc4d2d48f1ad267b1d5516487e |
| 출처 메모 | uspto-grants-2011_05 |