참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Lithium azide | HCID 88163 | — |
| 반응물 | 1,4-Anhydro-2-S-[(4-methoxyphenyl)methyl]-2-thio-L-arabinitol 5-(4-Methylbenzenesulfonate) | HCID 88337105 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1,4-Anhydro-5-azido-5-deoxy-2-S-[(4-methoxyphenyl)-methyl]-2-thio-L-arabinitol | HCID 131719993 | 32.6% |
반응 단계
A mixture of 2.0 g of product from Example 324, 0.460 g of lithium azide and 2 ml of N,N-dimethylformamide is stirred at 70° C. for 65 hours. The reaction mixture is concentrated in vacuo. The residue is purified by chromatography (Silica gel: 30% ethyl acetate/hexane) to give 0.454 g of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05623081 |
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| 출처 데이터셋 | uspto-grants-1997_04 |
|---|
| ORD ID | ord-5061bb5743e04cedafaf182a0c9038b8 |
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| 출처 메모 | uspto-grants-1997_04 |
|---|
