Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyanoacetic acid → (7-Methoxy-1-benzofuran-3-yl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyanoacetic acid | HCID 9740 | — |
| 반응물 | Ammonium Acetate | HCID 517165 | — |
| 반응물 | 7-Methoxybenzofuran-3(2H)-one | HCID 2818112 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | (7-Methoxy-1-benzofuran-3-yl)acetonitrile | HCID 15618729 | 30% |
반응 단계
The solution of 7-methoxy-1-benzofuran-3(2H)-one (reference) (7.5 g, 0.046 mol), cyanoacetic acid (19.55 g, 0.23 mol) and ammonium acetate (7.08 g, 0.092 mol) in xylene was refluxed for 16-18 h. using dean stark apparatus. Xylene was removed under diminished pressure. Brown black residue was taken in ethyl acetate, washed with water and concentrated. On purification on silica gel it yielded (7-methoxy-1-benzofuran-3-yl)acetonitrile (30%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07943634B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-ac3f40c2faa7422a8e9aaa0d2bc845a9 |
| 출처 메모 | uspto-grants-2011_05 |