Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 1-Methyl-3-(5H-pyrrolo[2,3-b]pyrazin-6-yl)-1H-indol-5-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 6-(5-methoxy-1-methyl-1H-indol-3-yl)-5H-pyrrolo[2,3-b]pyrazine | HCID 9860448 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 1-Methyl-3-(5H-pyrrolo[2,3-b]pyrazin-6-yl)-1H-indol-5-ol | HCID 22477232 | 94.8% |
반응 단계
A mixture of 6-(5-methoxy-1-methyl-1H-indol-3-yl)-5H-pyrrolo[2,3-b]pyrazine [200 mg, Example 1(a)] hydrobromic acid (48%, 500 μl) and glacial acetic acid (3 mL) was heated under reflux for 14 hours. After cooling the mixture was neutralised by addition of saturated sodium bicarbonate solution. The resulting dark solid was filtered and then dried to give the title compound (180 mg) as a black solid, m.p. 289-290° C. MS: 264 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07943616B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-bdec31d1594a40d0a02e007ce908d90c |
| 출처 메모 | uspto-grants-2011_05 |