Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminothiophenol → 2-(4-Aminophenylthio)-6-methoxyquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminothiophenol | HCID 14510 | — |
| 반응물 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 반응물 | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(4-Aminophenylthio)-6-methoxyquinoline | HCID 18971662 | — |
반응 단계
2-Chloro-6-methoxyquinoline (52.0 mmoles, 10.0 g), 4-aminothiophenol (52.0 mmoles, 6.5 g) and dimethylaminopyridine (52.0 mmoles, 6.3 g) were stirred for 16 hr in 250 ml ethanol. The reaction was condensed and purified by HPLC over silica gel eluted with 25-30% ethyl acetate/hexane to yield 2-(4-aminophenylthio)-6-methoxyquinoline. 8.5 g, 58% product. Mass spec (FD) 282. Calculated for C16H14N2OS: C, 68.06; H, 5.00, N, 9.92. Found: C, 68.04; H, 4.97; N, 10.02.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624937 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-08c795c675d44ec988099b77cf02e9b6 |
| 출처 메모 | uspto-grants-1997_04 |