Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methyl-5-pyrimidinecarboxylic acid → 4-methyl-pyrimidine-5-carboxylic acid (6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methyl-5-pyrimidinecarboxylic acid | HCID 14922219 | — |
| 반응물 | 6-Chloro-7-methoxy-9h-pyrido[3,4-b]indol-8-amine | HCID 21362743 | — |
| 용매 | Formic Acid | HCID 284 | — |
| 생성물 | 4-methyl-pyrimidine-5-carboxylic acid (6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-amide | HCID 11176085 | 80% |
반응 단계
The desired compound was prepared according to Method A from 6-chloro-7-methoxy-9H-beta-carbolin-8-ylamine and 4-methyl-5-pyrimidine carboxylic acid in 80% yield. 1H-NMR (300 MHz, DMSO-d6): δ 2.75 (s, 3H), 3.92 (s, 3H), 8.19 (d, 1H), 8.41 (d, 1H), 8.50 (s, 1H), 8.96 (s, 1H), 9.20 (s, 1H), 9.25 (s, 1H), 10.63 (s, 1H), 11.67 (s,1H). Retention Time (LC, method: formic acid standard): 0.95 min. MS (M+H+): 368.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07951801B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-c4100b6401c6453f8d2a9dce796bbb8a |
| 출처 메모 | uspto-grants-2011_05 |