Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylsilylacetylene → Methyl 5-((trimethylsilyl)ethynyl)nicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylsilylacetylene | HCID 66111 | — |
| 반응물 | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| 생성물 | Methyl 5-((trimethylsilyl)ethynyl)nicotinate | HCID 53821751 | 13.6% |
반응 단계
Under the conditions of example 21 B, 5 g of 5-bromonicotinic acid methyl ester is reacted with 2.43 g of trimethylsilylacetylene, worked up, and the crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate. 734 mg of 5-(2-trimethlsilylethinyl)-nicotinic acid methyl ester is obtained as oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624943 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-b32f6a6c03b1401f8f6ebe00916729cb |
| 출처 메모 | uspto-grants-1997_04 |