참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 3-(2-Thienyl)-1,2-dihydroquinoxalin-2-one | HCID 723698 | — |
| 생성물 | 2-Chloro-3-(2-thienyl)quinoxaline | HCID 2801655 | 74% |
반응 단계
A mixture of 3-(2-thienyl)quinoxalin-2(1 H)-one (500 mg, 2.19 mmol.) and POCl3 (6 mL) was heated to reflux at 120° C. After the material was consumed, the reaction mixture was taken up with water and ice. The solid was collected and dried in vacuo to give 2-chloro-3-(2-thienyl)quinoxaline (400 mg, 74%). 1 H NMR (400 MHz, CDCl3) δ 8.22 (d, J=4.8 Hz, 1 H), 8.00 (d, J=10.4 Hz, 1 H), 7.91 (d, J=10.4 Hz, 1 H), 7.72˜7.61 (m, 2 H), 7.52 (d, J=6.8 Hz, 1 H), 7.13 (t, J=6.0 Hz, 1 H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08048862B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-0d832703f8194eceb3554f988077721c |
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| 출처 메모 | uspto-grants-2011_11 |
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