참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phenacyl bromide | HCID 6259 | — |
| 반응물 | 4-Amino-pyrido[2,3-e]pyrimidin-2-one | HCID 19366879 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 135418313 | HCID 135418313 | — |
반응 단계
A mixture of 4-Amino-pyrido[2,3-e]pyrimidin-2-one (95 mg) and α-bromo-acetophenone (117 mg) in 4 mL of dimethylformamide (DMF) was heated at about 150° C. for 20 min. The reaction mixture was concentrated in vacuo and the residue was subjected to flash chromatography on silica gel with 10% methanol/methylene chloride as the eluent to afford 2-Phenylimidazo[1,2-c]pyrido[2,3-e]pyrimidin-5(6H)-one, (Compound 15), m.p. 329-330° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05625063 |
|---|
| 출처 데이터셋 | uspto-grants-1997_04 |
|---|
| ORD ID | ord-bbddf2a86d5348d1953f8495addc6942 |
|---|
| 출처 메모 | uspto-grants-1997_04 |
|---|
