Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pentafluorobenzyl bromide → HCID 59383141, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pentafluorobenzyl bromide | HCID 74484 | — |
| 반응물 | (2S,4S)-1-[[N-(4-carboxybicyclo[2,2,2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile | HCID 57634365 | — |
| 생성물 | HCID 59383141 | HCID 59383141 | 89.7% |
반응 단계
In a similar manner to Example 8, (2S,4S)-1-[[N-(4-carboxybicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile (30.0 mg) and 2,3,4,5,6-pentafluorobenzyl bromide (26.6 mg) were used to obtain (2S,4S)-4-fluoro-1-[[N-[4-(2,3,4,5,6-pentafluorobenzyl)oxycarbonylbicyclo[2.2.2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (41.9 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08053465B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-8c1b1bdf78cd42f384105cb04523b0bd |
| 출처 메모 | uspto-grants-2011_11 |