Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → ethyl 3-[N,N'-bis(benzyloxycarbonyl)hydrazino]-2,5-dioxopyrrolidine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,2-Bis(phenylmethyl) 1,2-diazenedicarboxylate | HCID 75557 | — |
| 반응물 | Ethyl 2,5-dioxo-3-pyrrolidinecarboxylate | HCID 23635561 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | ethyl 3-[N,N'-bis(benzyloxycarbonyl)hydrazino]-2,5-dioxopyrrolidine-3-carboxylate | HCID 58382718 | 94% |
반응 단계
To a solution of ethyl 2,5-dioxopyrrolidine-3-carboxylate (3.92 g) in ethyl acetate (60 ml) was added dibenzyl azodicarboxylate (7.27 g), followed by potassium carbonate (317 mg) at room temperature. After this mixture was stirred at room temperature for 1 hour, the mixture was filtered through a Celite pad. The filtrate was concentrated and the resulting residue was purified by a flash column chromatography (hexane:ethyl acetate=2:1) to give the ethyl 3-[N,N′-bis(benzyloxycarbonyl)hydrazino]-2,5-dioxopyrrolidine-3-carboxylate (10.1 g, 94%) as amorphous.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08058456B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-4faacf44633047b4ade76eefc09a49e6 |
| 출처 메모 | uspto-grants-2011_11 |